Martie Rhodes is a successful video game designer married to a good man named Dusty. Her best friend Susan suffers from agoraphobia (fear of open spaces) and stays locked up in her apartment everyday. She depends on Martie to take her to her weekly therapy sessions. Martie's life is turned upside down when she too becomes inflicted with a deadly fear - the fear of yourself and what you might do to others. Dusty begins a frantic search for clues to tell him what's going on. Unfortunately, Dusty begins to find himself inflicted with a condition that is even worse than Martie's.