When a desperate village elder learns that his daughter has been abducted by the vampire Noble Mayerling, he turns to the mysterious Vampire Hunter D to save her. However, with not just his daughter's life but her very soul in peril, her father also enlists the aid of the notorious Marcus clan, a dangerous and renegade family of Hunters as infamous for killing off the competition as they are for getting their man.

D's task becomes ever-more daunting as the fleeing Mayerling bends an entire village to his will, enlisting a horrific cadre of human/monster half-breeds. Powerful as D is, can he Prevail against the force of sheer numbers of such a diabolical adversaries?