The 1997 night that Hale-Bopp streaks across the skies over Vancouver, Liz Dunn has nothing in her life but impending oral surgery and an armful of schmaltzy video rentals to get her through her solitary convalescence in her sterile condo. She's overweight, crabby, and plain, but behind her eyes lurk whole universes that she's never had the opportunity to express. Just as Liz makes a quiet decision to seek peace in her life rather than certainty, along comes another comet, in the form of a young man admitted to the local hospital with her name and number inscribed on his Medic Alert bracelet: In case of emergency, contact Liz Dunn.

A charming lost soul and a strange visionary, Jeremy upends Liz's quiet existence, triggering a chain of events that take her to the other side of the world and back, endangering her life just as a real chance at happiness finally seems within reach.