The alien leader Diana has renewed her pledge to break the resistance. At a laboratory hidden in the Everglades, a diabolical experiment is underway to bring success to her scheme. There, pro-football star Jack Stern and his fiancee, biologist Sabrina Fontaine, are unwilling participants in the creation of a "master race" - human-reptilian hybrids of super-strength, bred to become soldiers against the resistance.

But even now, the leaders of the resistance are racing south to the alien's Everglades hideout, and into a battle that must smash... The Florida Project.