Meet the little known and even less understood heroes of police work in Las Vegas - the forensic investigators. Led by veteran Gil Grissom, the remarkable team assigned to the Criminalistics Bureau's graveyard shift - including Catherine Willows, Warrick Brown, Nick Stokes, and Sara Sidle - must combine cutting-edge scientific methods and old-fashioned savvy as they work to untangle the evidence behind the yellow police tape.

Wednesday, 5:30 AM: in an off-the-strip, somewhat-out-of-the-way casino, a room-service waiter rounds a corner and stumbles across a killer - and a corpse. Homicide detective Jim Brass summons Grissom and company to the scene. As Brass follows his insticts, Warrick and Sara follow evidence the killer left behind, and Nick and Catherine investigate a murder that's fifteen years new. Although focused at first on the perpetrator's deadly double-tap signature, Grissom will soon make the most troubling discovery of all: the inexplicable interest of FBI agent Rick Culpepper.