Sylvia Bryan has been feeling weak and tired, but is shocked when her internist finds a malignant lump in her breast. She and her husband can't understand why God is allowing cancer to attack at a time when their missionary work is going so well.

As Sylvia undergoes a mastectomy and chemotherapy, the rest of the neighbors pull together to support her, even while coping with the stress of their own lives. Steve and Cathy experience problems with their blended family. Tory and Barry struggle to raise their Down Syndrome child. Brenda's husband, David, who is not a believer, watches from the sidelines.