Thatcher Dryden, former drug kingpin and now leader of the megacorporation Dryco, intends to supply a waiting world with the Messiah it so desperately seeks. But Lester Macaffrey, a schoolteacher found performing miracles among the human flotsam of the Lower East Side, proves no more controllable than any Messiah. While Thatcher's minions scheme to sell the world salvation with a Dryco label on it, Thatcher's own mistress is strangely drawn to Macaffrey - and begins to be transformed into something new and strange...something that might change the world.