Princeton. Good Friday, 1999. On the eve of graduation, two students are a hairsbreadth from solving the mysteries of the Hypnerotomachia Poliphili. Famous for its hypnotic power over those who study it, the five-hundred-year-old Hypnerotomachia may finally reveal its secrets -- to Tom Sullivan, whose father was obsessed with the book, and Paul Harris, whose future depends on it. As the deadline looms, research has stalled -- until an ancient diary surfaces. What Tom and Paul discover inside shocks even them: proof that the location of a hidden crypt has been ciphered within the pages of the obscure Renaissance text.

Armed with this final clue, the two friends delve into the bizarre world of the Hypnerotomachia -- a world of forgotten erudition, strange sexual appetites, and terrible violence. But just as they begin to realize the magnitude of their discovery, Princeton's snowy campus is rocked: a longtime student of the book is murdered, shot dead in the hushed halls of the history department.