Edited by: Martin H. Greenberg and Carol-Lynn Rössel Waugh

Published to celebrate the centennial of the publication in 1887 of "The Speckled Band," the first story published by Arthur Conan Doyle to feature his now immortal Sherlock Holmes. Contains the following stories:

• The Infernal Machine by John Lutz
• The Final Toast by Stuart M. Kaminsky
• The Phantom Chamber by Gary Alan Ruse
• The Return of the Speckled Band by Edward D. Hoch
• The Adventure of the Unique Holmes by Jon L. Breen
• Sherlock Holmes and "The Woman" by Michael Harrison
• The Shadows on the Lawn by Barry Jones
• The Adventure of the Gowanus Abduction by Joyce Harrington
• Dr. and Mrs. Watson at Home by Loren D. Estleman
• The Two Footmen by Michael Gilbert
• Sherlock Holmes and the Muffin by Dorothy B. Hughes
• The Curious Computer by Peter Lovesey
• The Adventure of the Persistent Marksman by Lillian de la Torre
• The House That Jack Built by Edward Wellen
• The Doctor's Case by Stephen King
• Afterword: Moriarty and the Real Underworld by John Gardner